Hi Prakash , Estriol can be used topically on the face. It will help to minimize Acne Rosacea, fine lines and wrinkles, helps nutrients and oxygen circulate, increases moisture in the skin and can minimize sebum production. There are some common side effects for long term use of Estriol cream for Acne Rosacea. Depending on its severity, acne can cause emotional distress and scar the skin. The earlier you start treatment, the lower your risk of such problems. Acne Rosacea signs vary depending on the severity of the condition. Homeopathy is one of the best treatments for acne, its treatment for acne, it treats from the root and doesn’t cause any side-effects. Some indicated Homoeopathic remedies for Acne Rosacea are Hepar sulph, Sulphur, Kali.sulph, Psorinum, Cal.sulph, Ant.crud etc. Better to take doctor’s advice before taking medicines. Please call on +918885920000 for more details about medicines and online consultation. “A Healthy outside starts from the inside”. Stay Healthy with one of the “Best Homeopathic treatments” @ Dr. AnkiReddy’s clinic